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The Benefits and Side Effects of CBD Oil [Backed by Science]

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The Benefits and Side Effects of CBD Oil

Cannabidiol (CBD) products are becoming increasingly popular in the last few years. It’s not difficult to comprehend why this organic compound could be beneficial for a diverse range of conditions and symptoms.

CBD is not psychomimetic, which means that it doesn’t trigger the intoxicating effects that its close relative THC is renowned for.

Primarily involved in interacting with the body’s endocannabinoid system (ECS) and also through a complicated chemical ‘second messenger’ system within the body and brain, which helps maintain a healthy level of equilibrium, also known as homeostasis, by controlling significant functions like emotions, pain, brain functioning, and metabolism.

The initial studies have shown that CBD and other cannabinoid-based treatments could help in various issues, from anxiety to challenging-to-treat symptoms or conditions like chronic pain.

Based on research, this is a more detailed look at CBD oil’s benefits. CBD oil.

1. Depression and Anxiety

Depression and anxiety are the two most commonly reported mental health conditions globally. There’s evidence to suggest that CBD could aid in the treatment of anxiety in humans. At present, in an animal model, CBD has been shown to possess antidepressant properties. However, it’s not yet proven in humans. Certain medical cannabis strains have been proven to assist with depression and mixed anxiety/depression within clinical practices.

Researchers believe that CBD may be helpful in different types of anxiety disorders, such as generalized anxiety disorder and post-traumatic stress disorder (PTSD), and obsessive-compulsive disorder.

In contrast to the placebo study, one Brazilian study showed that a dose of 600 mg of pure CBD reduced anxiety triggered by public speaking for people suffering from Social Anxiety Disorder (SAD).

Similar to this, a Japanese study revealed findings that CBD oil reduced anxiety among teenagers who suffer from SAD. In contrast, the placebo did not have any effects.

Animal studies have also suggested that CBD may have antidepressant properties. A case study of a woman suffering from depression and anxiety due to drug addiction found CBD treatment to be effective. CBD treatment helped to reduce “depressive as well as anxiety symptoms.” Researchers believe that CBD creates its antidepressant and anxiety-relieving effects through interaction with the ECS and receptors to serotonin and the neurotransmitter known as the calming (brain chemical) GABA.

2. Sleep

Sleep disorders and insomnia constitute the majority of prevalent ailments that affect people worldwide. Like all cannabis, CBD may offer some assistance.

One study shows that people who suffered from insomnia or anxiety were prescribed CBD capsules each day for three months. The first month was the most successful 79% of participants experienced an anxiety reduction, and 67% experienced an improvement in sleep as a side benefit. Another study showed that CBD helped alleviate symptoms of REM sleep disorder. Evidence suggests medical cannabis could help people suffering from sleepless leg syndrome (RLS).

Researchers aren’t sure what CBD can directly help with sleep. However, one of the leading causes of poor or unrestful sleep can cause tiredness during the day, and a lower quality of life comes due to anxiety and stress. We know CBD helps reduce anxiety and stress levels and may alter stress hormones’ levels and eliminate barriers to good sleep.

CBD could also affect specific aspects of sleep via its effects on various brain neurotransmitters like serotonin and GABA, one of the brain-calming chemicals. Still, we don’t yet understand the precise process. Its pain and inflammation-relieving effects might also help since these issues can keep you awake at night, and this is especially this case with medical cannabis, which also contains

3. Inflammation and Pain

The signs of inflammation and pain can manifest in symptoms like soreness following exercise or chronic pain resulting from multiple ailments, such as multiple sclerosis, cancer, and arthritis.

Cannabis, used for pain relief for long periods and chronic pain, is the most frequently-cited health condition which qualifies for the use of medical cannabis. Because CBD is a significant element of cannabis, it’s not surprising that it has pain-relieving properties.

Its benefits can alleviate inflammation and pain through two methods. First, it could aid in regulating pain signals through the ECS via various signaling pathways. Furthermore, CBD interacts with multiple receptors that control inflammation and pain like TRPV1. A study on animals found an application of topical gel with CBD alleviated inflammation and pain in mice suffering from arthritis. Similar to this, a study on Sativex which contains CBD and THC, has shown improvements in chronic pain among patients suffering from rheumatoid joint. Patients who take medical cannabis have also reported that it helps treat pain related to autoimmune arthritis and similar disorders, typically having high CBD varieties.

Sativex also eased discomfort in another study of patients suffering from M.S. In addition, the Uruguay study showed that CBD helped reduce pain after kidney transplants in patients who are elderly.

A more exciting 2020 study explored whether the full-spectrum CBD hemp oil could aid chronic pain sufferers cut down on the use of prescribed opioid painkillers. In total, 97 patients took CBD oil for eight weeks in addition to their regular medications.

In the final study, nearly half of participants reduced or completely stopped their use of opioids, with 94% of them saying that CBD helped improve their lives, especially with sleeping and pain.

The evidence indicates that CBD has powerful anti-inflammatory properties and could ease different types of pain, particularly when combined with THC. Additionally, CBD helps anxiety sufferers feel chronic pain because of their chronic pain. That affects brain regions that are influenced by anxiety, mood, and stress.

4. Cancer

Cannabinoids are a brand new and exciting new field of research in cancer treatment. Presently, medical cannabis that contains both CBD and different quantities of THC could be beneficial in improving the patient’s health, the symptoms of cancer, and the side effects of chemotherapy when taken under the guidance of a medical professional.

One study examined the effectiveness of THC in conjunction with or without CBD for patients suffering from advanced cancer pain that is treatment resistant. The only CBD combined with the THC group experienced decreased pain, and 43% of patients reported improvement by 30 percent or more.

A study on rats that used CBD has shown that it could possess antiemetic (anti-vomiting) characteristics precisely like THC that are especially beneficial for the adverse consequences of chemotherapy. However, in the human body, CBD is not proven to work to be effective in this regard, and THC-containing medicinal cannabis has been identified as the remedy of choice to treat nausea and vomiting. It is also used with CBD to help buffer potential THC adverse effects.

This was confirmed in a study that showed the synthetic drug form of THC alone was able to reduce nausea induced by chemotherapy among cancer patients. A study conducted in mice showed that CBD helped ease the pain in the neuromuscular system due to the chemotherapy drug Paclitaxel.

CBD or medical cannabis may help with anxiety as well as sleeping disorders, which have a higher chance of being experienced by cancer patients.

A second study on mice found that CBD has chemopreventive benefits, which protect animals from the development of colon cancer.

In general, CBD offers numerous benefits for cancer patients, particularly when combined with THC. But, the preclinical evidence isn’t enough, and further human studies are required to prove its natural anti-cancer properties, as different cancers respond differently to each cannabinoid and at different doses could have opposing effects on tumors. Even within a particular cancer type, the receptors for cannabinoids in the tumor may influence the anti-cancer benefits CBD and other cannabinoids could possess, so there are many questions to answer regarding the best way to target certain cannabinoids on specific types of tumors.

5. CBD for Multiple Sclerosis

Multiple Sclerosis (M.S.) is an ongoing condition that affects the central nervous system of your body, which can cause swelling, temporary lesions, and occasionally neuropathic pain. Acute neuropathic pain could be one of the initial symptoms of the condition known as multiple Sclerosis or could indicate a return. There are a few signs of M.S., which can be cured or improved with the help of CBD.

Certain people prefer using CBD to treat the chronic pain that comes to M.S. CBD has many advantages for health, making it a popular and beneficial alternative for those with conditions like MS. Sativex, the first cannabis-based medication in the U.K., will likely prove effective for this condition.

A study published in Front Neurol, 2018 states that products with a CBD-to-THC ratio of 1:1 could significantly reduce the pain, muscle tightening, and stiffness associated with M.S. Another benefit of CBD is that it contains natural anti-inflammatory properties, which can assist in improving mobility and decreasing fatigue-related inflammation in people who suffer from M.S.

The benefit of the use of CBD to treat the symptoms of M.S. is that it has been proven that it works on humans. Many other CBD clinical trials have been conducted using rats and mice and require more medical research.

6. Neuroprotection

Neurodegenerative diseases like Parkinson’s disease, Alzheimer’s disease, and Huntington’s diseases are some of the most difficult to treat conditions available. They have the loss of neuron function and structure with each other.

Numerous studies have demonstrated that CBD can protect neurons.

In a mouse study, CBD reversed or stopped thinking problems related to cognitive decline. The same study showed that CBD helped to prevent an increase in memory impairment in rats suffering from dementia (A.D.).

In addition, a promising 2019 pilot study examined results from cannabis oil that contains the ratio of 2:1 CBD and THC for people who have severe dementia.

The treatment did not just improve patients’ behavior but also reduced the need for daily care. In addition, half of the participants could decrease or eliminate the use of other prescription drugs.

Additionally, positive outcomes have been observed in studies that have been conducted on Parkinson’s disease (P.D.). In one study, 300 mg doses of CBD enhanced the living quality of patients with P.D. compared to placebo, which was not able to improve. Another study showed that CBD helped with psychosis as a symptom seen in certain types of P.D.

7. Epilepsy

If there’s one advantage of CBD that is supported by a wealth of evidence, it’s the one that’s been recommended by doctors; it’s a reduction of the treatment-resistant forms of epilepsy.

The first and sole pharmaceutical product that contains CBD that is pure was approved in the last few months to treat seizures, like Dravet syndrome and Lennox-Gastaut disorder, which are two scarce epilepsy types that affect kids. CBD for treatment for epilepsy seems promising, but it requires an additional study before we can proceed beyond the evidence of anecdote.

In numerous randomized clinical trials, the gold standard for medical research was found to be Epidiolex significantly reduced the frequency of seizures among children suffering from these disorders.

In addition, numerous other studies have also revealed that CBD aids in treating epilepsy. A review paper of 36 research studies concluded that CBD could decrease seizures and stop them for some individuals.

Researchers believe that CBD can be effective by removing abnormal neuron activity, which causes seizures.

8. Cardiovascular Health

There is also evidence emerging that CBD has numerous beneficial effects on heart health and other parts of the cardiovascular system.

In one way, CBD may lower blood pressure, one of the main danger factors that can lead to stroke and other cardiovascular illnesses. One study showed that CBD decreased resting blood pressure and also reduced the increase in blood pressure that occurs during stress-related situations.

CBD can also help protect against atherosclerosis, which is the accumulation of plaque on the walls of blood vessels. This was proved by a research study in which CBD prevented the human coronary artery cells from the damage caused by high blood sugar.

Research has also proven the possibility that CBD can:

Aid with cardiovascular myopathy and other complications of the cardiovascular system caused by diabetes in animals. Guard against stroke by increasing cerebral blood flow in stressed mice

9. Skin Health

The ECS is found throughout the body and includes the skin, the largest organ in our body.

It plays a crucial function in maintaining the health of your skin by controlling various viral processes like inflammation and the growth of cells. Evidence suggests that ECS dysfunction can be found in numerous skin diseases like eczema, psoriasis, and acne.

This is why CBD could have a role to play in promoting the skin’s health.

One study recently examined the effectiveness of a CBD-infused topical Ointment for people suffering from eczema, psoriasis, and scarring caused by the above and other inflammatory skin conditions.

In 90 days, participants noticed improvements in hydration and skin elasticity and improvement in signs of psoriasis-like acne, scarring, and other indicators of skin health.

Another study investigated CBD’s effects CBD on sebocytes in humans, which are the cells of the skin that produce sebum, an oily substance that plays an essential role in acne.

CBD decreased inflammation and reduced sebum production and new sebocytes. This led a study to suggest the following “CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris.”

10. Arthritis

The latest research on animals suggests that there is the possibility that CBD can reduce inflammation and relieve pain; however, this needs to be verified through clinical studies on humans. There are numerous anecdotal accounts from people who have used CBD in arthritis treatment that have noted discomfort reduction and have even experienced better sleep.

The application of topical CBD can alleviate pain and effectively treat arthritis since it can help reduce inflammation. But, at present, there’s no scientific evidence to provide a definitive answer regarding whether CBD is a viable therapy for joint pain.

If you’re taking medication to treat arthritis, It is not recommended to utilize CBD as a substitute for prescription medication.

11. CBD for Lupus

It is an immune disorder that is typically characterized by inflammation within the system of immunity, which can cause it to attack its tissues. There is an unsolved issue with Lupus, so finding treatments that can alleviate the symptoms of Lupus is vital for those who suffer.

CBD may help relieve certain kinds of flare-ups and relieve the symptoms. CBD is a powerful anti-inflammatory drug and is free of harmful adverse effects, which makes it a good choice for those who suffer from Lupus. This is due to the fact that CBD inhibits the release of inflammatory proteins while stopping pain signaling within the brain. This happens because CBD is a receptor for TRPV1-cells.

The most effective type of CBD to test for Lupus is full-spectrum CBD because you will benefit from the entire spectrum of cannabinoids in the effect of an entourage. Before attempting CBD products to treat your ailments, make sure you consult your doctor because CBD may interact with other medications prescribed for people who have Lupus.

12. Digestive Health

Initial studies suggest that CBD may be beneficial for digestive issues like abdominal pain and nausea and for conditions like IBD, an inflammatory bowel disorder (IBD).

In one study, CBD-rich cannabis extract increased the quality of life and the symptoms of ulcerative colitis. 

13. Drug Dependence

A significant and exciting field that is the subject of CBD research in addiction treatment. CBD isn’t addictive, and there’s evidence to suggest that it may reduce cravings for several popular drugs, like nicotine and opioids.

One study that included 24 smokers examined whether CBD could help them stop smoking. The inhalers they used contained CBD or a placebo every day for a whole week.

The CBD group had 40% fewer cigarettes throughout the study, and some smokers maintained this decrease after the study. Studies in rodents indicate that CBD may decrease cravings for cocaine and alcohol. CBD is also able to help users to quit smoking marijuana. A study of 94 users revealed that those who consumed high-CBD varieties of marijuana scored higher on the scale of addiction ratings for cannabis. Similar to a case study of an individual suffering from depression, anxiety, insomnia, and other signs of withdrawal syndrome revealed that CBD was the cause of a significant improvement. CBD could also be beneficial in the treatment of addiction to opioids. A study of addicts to heroin analyzed whether CBD could help reduce cravings for opioids. They consumed CBD for three days. While the placebo treatment was ineffective, CBD significantly reduced opioid cravings, and the effects lasted for a week following the completion of the study.

CBD is a promising drug that highly-respected researcher and neuroscientist Yasmin Hurd believes is a viable option to fight the U.S. opioid crisis. The widespread use of non-prescription and prescription opioids causes hundreds of thousands of deaths due to overdose each year.

14. Diabetes

Research has shown that CBD could have an effect positive over type 1 diabetes and complications associated with diabetes, including nerve damage.

Numerous studies on mice have proven that CBD can delay and stop the development of type 1 diabetes, primarily through its anti-inflammatory effects and shift of the immune system away from the process of developing diabetes and the destruction of pancreatic cells.

Evidence from animal research also suggests that CBD could be beneficial in treating issues related to diabetes, which include:

Diabetic cardiomyopathy (heart muscle disorder) Diabetic retinopathy (damage to the eyes) Diabetic neuropathy, a kind of nerve damage

15. Migraines

There’s increasing evidence that migraines and other conditions that are difficult to treat result from clinical endocannabinoid deficiencies (CEDC) impaired endocannabinoid function.

We know that CBD can help by possibly modulating the levels of endocannabinoids in the body. It could be an avenue through which CBD may help relieve migraines.

However, evidence from clinical research is needed to prove the theory.

The Side Effects

CBD could improve your health in various ways; however, does it come with any possible side effects? The good thing is that one of the main reasons CBD is so well-known is that it’s easily absorbed by the majority of people, particularly at non-prescription wellness doses that are not under the supervision of a physician.

CBD may trigger some adverse negative effects; however, they are scarce, minor, and short-lasting. The possible risks and side effects can include dry mouth, diarrhea, lightheadedness, fatigue, low blood pressure, and changes in weight or appetite; however, in the doses for wellness employed, these effects are infrequent. The majority of the time, the results have only been observed in studies that utilized large dosages of 100% pure CBD (300 milligrams or greater per day) far higher than the dosages used typically within OTC CBD wellness products.

Animal studies suggest that CBD may also enhance or, in certain instances, decrease the efficacy of certain medications and prescription medications by altering the liver CYP450 enzymes. However, most of these interactions are not published and therefore not clinically relevant. However, certain types of drugs may be more prone to risk.

CBD doesn’t have any effects on addiction and doesn’t cause withdrawal, and there’s no evidence of it causing tolerance when used frequently for extended periods.

Summarizing the Benefits of CBD

CBD has been extensively studied, which suggests that it could provide benefits to many commonly encountered issues like stress, anxiety poor sleep, in addition to numerous chronic illnesses and signs at different dosages.

While more high-quality research on human health is required to confirm CBD’s health benefits, the existing evidence suggests it’s a non-toxic compound with no adverse side effects. It provides a natural remedy to numerous common wellness problems. Numerous health benefits can be from Cannabis plants. Products derived from the Cannabis Sativa plant, like hemp seed oil and CBD oil, have plenty to offer, and we’re sure to witness advancements in the field of medical marijuana.

It’s still advisable to talk with your physician before beginning to take CBD in the very first instance, particularly in the case of prescription medications.

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